Stabilized liposome/amphotercin B composition and method
US5180713A · kind A · utility
15Cited by
1References
1Claims
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Assignee
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Key dates
| Filing date | Dec 14, 1990 |
| Grant date | Jan 19, 1993 |
| Priority date | — |
| Expiry date | Dec 14, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/7048
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of administering a liposome/amphotericin B composition having a predetermined size distribution in 0.2-0.5 micron size range. The method includes preparing a suspension of heterogeneously sized amphotericin B liposomes in an aqueous solution containing at least about 0.5% w/v of membrane-stabilizing agent. After sizing to the desired size distribution, and before the liposome sizes change substantially, the suspension is lyophilized for storage. After reconstituting the lyophilized material, the resulting suspension is administered before a substantial size changes in the liposomes occur.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.