6-azido-2-fluoropurine, useful in the synthesis of nucleosides
US5180824A · kind A · utility
10Cited by
7References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 29, 1990 |
| Grant date | Jan 19, 1993 |
| Priority date | — |
| Expiry date | Nov 29, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention pertains to novel methods of synthesizing fludarabine, fludarabine phosphate and related nucleoside pharmacologic agents utilizing 6-azido-2-fluoropurine as a novel intermediate. In particular this invention pertains to a synthesis of fludarabine where the relatively low yield fluorination step is done before the costly coupling step.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.