Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A · kind A · utility
94Cited by
11References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1991 |
| Grant date | Jan 26, 1993 |
| Priority date | — |
| Expiry date | Feb 14, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/124
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aerosol formulations for use in metered dose inhalers are disclosed which include 1,1,1,2-tetrafluoroethane alone and in combination with other compounds as well as various hydrocarbon blends. The density, vapor pressure, flame extension characteristics, dispersability of medicant, dissolvability of surfactant, respirable fraction, and compatibility elastomer seals for the aerosol formulations have been examined. The aerosol formulations are attractive alternatives to chlorofluorocarbon based aerosols since they do not deplete the ozone layer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.