Use of pure histones H1 and H2A:H2B dimers in therapeutic methods

US5182257A · kind A · utility

Assignee

• Volker Rusch · DE

Inventors

• Michael Zeppezauer · Scheidt, DE
• Robert Reichhart · Homburg, DE

Key dates

• Filing date: Apr 3, 1989
• Grant date: Jan 26, 1993
• Expiry date: Apr 3, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to the use of pure histones H1, H2A, H2B, H2A:H2B, H3 as hormonal or hormon-like active substance for the preparation of pharmaceuticals for the immuno-therapy, for the therapy of endocrine disturbance and for cancer therapy. Instead of the histones also their evolutionary variable sections or at least one partial section of at least five aminoacid residues of at least one evolutionary variable histon section can be used.