DNA sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
US5182260A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Nov 1, 1989 |
| Grant date | Jan 26, 1993 |
| Priority date | — |
| Expiry date | Nov 1, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/856
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to polypeptide inhibitors of platelet activation and derivatives thereof, purified from the venom of the North American Water Moccasin and to methods for their purification. This invention also relates to DNA sequences and recombinant DNA molecules which code for these polypeptide inhibitors of platelet activation. And this invention relates to recombinant DNA molecules which code for fusion proteins comprising both a polypeptide inhibitor of platelet activation and an anti-thrombin polypeptide. This invention also relates to pharmaceutically acceptable compositions and methods characterized by at least one of these natural or recombinant inhibitors of platelet activation, alone or in combination with anti-thrombin compounds. The compositions, combinations and methods of this invention are particularly useful in the treatment of thrombotic diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.