Analgesic benzoxazolinones having at the 6-position a 1-hydroxy-3-morpholinopropyl side chain
US5182278A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 29, 1991 |
| Grant date | Jan 26, 1993 |
| Priority date | — |
| Expiry date | Jul 29, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of general formula (I): ##STR1## in which: R.sub.1 denotes a hydrogen atom or a lower alkyl optionally substituted with a hydroxyl group, PA0 R.sub.2 and R.sub.3 : PA0 a- identical or different, denote a hydrogen atom, a lower alkyl, a lower alkenyl, a substituted or unsubstituted aryl, a substituted or unsubstituted (lower alkyl)aryl, PA0 b- are such that they form, with the nitrogen which carries them, a saturated or unsaturated, mono- or bicyclic heterocyclic system containing at most 3 hetero atoms per ring, substituted or unsubstituted, with the exception of 1-arylpiperazine systems, PA0 X denotes a hydrogen atom, PA0 Y denotes a hydrogen atom or a hydroxyl, or alternatively X and Y denote an oxygen atom, provided that PA0 R.sub.1 is then other than a methyl group, PA0 Z denotes a hydrogen atom or forms a .pi. bond with Y, and PA0 T denotes a hydrogen atom or a lower alkyl, their stereoisomers and their quaternary ammonium salts, as well as their addition salts with a pharmaceutically acceptable acid having analgesic or arterial antihypertensive property. Medicinal products.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.