Pyrozala-pyridyl aminoabkoxyphenol compounds

US5182291A · kind A · utility

Assignee

• Sanofi · FR

Inventors

• Jean Gubin · Brussels, BE
• Pierre Chatelain · Brussels, BE
• Marcel Descamps · Kraainem, BE
• Dino Nisato · Pavia, IT
• Henri Inion · Wemmel, BE
• Jean Lucchetti · Chastre, BE
• Jean-Marie Mahaux · Brussels, BE
• Jean-Noel Vallat · Toulouse, FR

Key dates

• Filing date: Jun 17, 1991
• Grant date: Jan 26, 1993
• Expiry date: Jun 17, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Aminoalkoxyphenyl derivatives useful in the treatment of certain pathological syndromes of the cardiovascular system of formula: ##STR1## in which: B represents a --S--, --SO-- or --SO.sub.2 -- group, PA1 R.sub.1 and R.sub.2, which are identical or different, each denote hydrogen, a methyl or ethyl radical or a halogen, PA1 A denotes a straight- or branched-alkylene radical having from 2 to 5 carbon atoms or a 2-hydroxypropylene radical, in which the hydroxy is optionally substituted by a lower alkyl radical, PA1 R.sub.3 denotes an alkyl radical or a radical of formula: EQU --Alk--R.sub.5 in which Alk denotes a single bond or a linear- or branched-alkylene radical having from 1 to 5 carbon atoms and R.sub.5 denotes a pyridyl, phenyl, 2,3-methylenedioxyphenyl or 3,4-methylenedioxyphenyl radical or a phenyl group substituted with one or more substituents, which may be identical or different, selected from halogen atoms, lower alkyl groups or lower alkoxy groups, PA1 R.sub.4 denotes hydrogen or an alkyl radical or PA1 R.sub.3 and R.sub.4 when taken together, denote an alkylene or alkenylene radical having from 3 to 6 carbon atoms and optionally substituted with a phenyl radical or opt…