Paramagnetic chelates

US5182370A · kind A · utility

Assignee

• Bracco - Industria Chimica S.p.A. · IT

Inventors

• Ernst Felder · Lugano, CH
• Luciano Fumagalli · Milano, IT
• Fulvio Uggeri · Codogno, IT
• Giorgio Vittadini · Milano, IT

Key dates

• Filing date: Dec 13, 1989
• Grant date: Jan 26, 1993
• Expiry date: Dec 13, 2009

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Comounds having the formula ##STR1## wherein: a is 2 or 3; b is an integer from 0 to 4; PA0 Me.sup.(a+) is an ion of an element of atomic number from 57 to 70 or an ion of a transition metal of atomic number 21-29, 42 or 44; PA0 E.sup.(b+) is one or more physiologically biocompatible cation of an inorganic or an organic base or amino acid, said cation representing a total positive charge of b units; PA0 S is the group --A--O--R wherein: PA1 A is --(CH.sub.2).sub.m --; --CH.sub.2 --C(CH.sub.3).sub.2 --; m is an integer from 1 to 5; R is H; linear or branched alkyl of 1 to 8 carbon atoms, said carbon atoms being unsubstituted or substituted by one or more hyroxy group; aralkyl of 1 to 4 aliphatic carbon atoms; phenyl or phenyl substituted by halogen, amino, hydroxy or trifluoromethyl; (poly)-oxa-alkyl of 1 to 10 oxygen atoms and from 3 to 30 carbon atoms; PA0 R.sub.1 is R.sub.2 or --CH.sub.2 COOZ; --CH(CH.sub.3)COOZ; --(CH.sub.2).sub.n --N(CH.sub.2 COOZ).sub.2 ; hydroxy-arylalkyl radical in which the aryl radical is unsubstituted or substituted by hydroxy; PA0 R.sub.2 is --CH.sub.2 COOZ; --CH(CH.sub.3)COOZ; with the proviso that when R.sub.1 is --CH.sub.2 COOZ or --CH(CH.sub.3)COOZ, …