Certain imidazoquinoxalinones; a new class of gaba brain receptor ligands
US5182386A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 27, 1991 |
| Grant date | Jan 26, 1993 |
| Priority date | — |
| Expiry date | Aug 27, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention encompasses compounds of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are variables; PA0 X and Y represent hydrogen, halogen, hydroxy or amino substituents, with the proviso that when Y is a hydrogen, halogen, or amino substituent, X is hydroxy; and PA0 W represent aryl groups unsubstituted or substituted with halogen, hydroxy, alkyl, alkoxy or amino groups. These compounds or prodrugs thereof are highly selective agonists, antagonists or inverse agonists or GaBAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorder, overdose with benzodiazepine drugs, and enchancement of memory.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.