Starch encapsulation of biologically active agents by a continuous process
US5183690A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 25, 1990 |
| Grant date | Feb 2, 1993 |
| Priority date | — |
| Expiry date | Jun 25, 2010 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J13/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biologically active agents to be encapsulated are continuously blended with a starchy material and water, subjected to high-shear mechanical action at a temperature above the gelatinization temperature of starch, and continuously recovered as an insolubilized matrix of starch that entraps discontinuous domains of the agent. Alternatively, the core material to be encapsulated is added and blended with the aqueous dispersion of starch after the starch and water have been subjected to an elevated temperature sufficient to gelatinize the starch. Rate of release of agents to the environment can be controlled by preselecting a set of conditions related to various processing parameters. Encapsulation of biologically active compositons provides protection against degradative environmental conditions, improves safety in handling, and slows the release of such compounds to the surrounding medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.