Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents

US5183925A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Josef Heindl · Berlin, DE
• Werner Skuballa · Berlin, DE
• Bernd Buchmann · Hohen Neuendorf, DE
• Wolfgang Frohlich · Berlin, DE
• Rolalnd Ederdt · Berlin, DE

Key dates

• Filing date: Nov 19, 1990
• Grant date: Feb 2, 1993
• Expiry date: Nov 19, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C59/68
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to leukotriene-B.sub.4 derivatives of formula I, ##STR1## in which n=1-10, PA1 R.sub.1 means radical CH.sub.2 OH, radical COOR.sub.4, radical CONHR.sub.5 or radical CONR.sub.6 R.sub.7, PA1 A means a cis, trans or trans, trans--CH.dbd.CH--CH.dbd.CH group or tetramethylene group, PA1 B means an alkylene group with up to 10 C atoms, PA1 D means a direct compound, oxygen, sulfur, a --C.tbd.C group or a --CH.dbd.CR.sub.8 group, PA1 B and D together mean a direct bond, PA1 R.sub.2 means a hydrogen atom or an acid radical of an organic acid with 1-15 C atoms and PA1 R.sub.3 means a hydrogen atom, an optionally substituted alkyl radical with 1-10 C atoms, PA1 a cycloalkyl radical with 3-10 C atoms, an optionally substituted aryl radical with 6-10 C atoms or a 5-6 member heterocyclic radical and if R.sub.4 means a hydrogen atom, their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their pharmaceutical use.