Microbial transformation of a substituted pyridinone using actinoplanacete sp. MA 6559
US5185251A · kind A · utility
39Cited by
6References
3Claims
0Family size
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Key dates
| Filing date | Jun 7, 1991 |
| Grant date | Feb 9, 1993 |
| Priority date | — |
| Expiry date | Jun 7, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/822
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fermentation of the microorganism Actinoplanacete sp. (MA6559), ATTC No. 53771, in the presence of the HIV reverse transcriptase inhibitor ##STR1## yields 3-[2-(benzoxazol-2-yl)ethyl]-5-(1-hydroxyethyl)-6-methyl-2(1H)-pyridinone and 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-hydroxymethyl-2(1H)-pyridinone, both of which are useful in the prevention or treatment of infection by HIV and the treatment of AIDS.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.