Thioformamide derivatives

US5185375A · kind A · utility

Assignee

• May & Baker, Ltd. · GB

Inventors

• David C. Cook · London, GB
• Terance Hart · Chapel-en-le-Frith, GB
• Iain McFarlane McLay · Romford, GB
• Malcolm Norman Palfreyman · Romford, GB
• Roger J. A. Walsh · Romford, GB

Key dates

• Filing date: Mar 30, 1990
• Grant date: Feb 9, 1993
• Expiry date: Mar 30, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C327/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Therapeutically useful thioformamide derivatives of the formula: ##STR1## wherein R represents alkyl, Ar represents optionally substituted phenyl group, Y represents ethylene, methylene or a valency bond, and X represents carbonyl, hydroxymethylene, >C.dbd.NOR.sup.1, >C.dbd.NN(R.sup.1).sub.2 or >C.dbd.NN(R.sup.1)CON(R.sup.1).sub.2 in which R.sup.1 represents hydrogen or optionally substituted alkyl, benzyl, phenethyl, 1-naphthylmethyl, 2-naphthylmethyl or pyrid-3-ylmethyl or two R.sup.1 substituents on the same nitrogen atom may together form optionally substituted alkylene, and salts thereof, processes for their preparation and compositions containing them are described.