Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
US5185444A · kind A · utility
795Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 21, 1991 |
| Grant date | Feb 9, 1993 |
| Priority date | — |
| Expiry date | Nov 21, 2011 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, chiral linkages, one-three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.