Method for in vivo measurement of oxygen concentration levels
US5186173A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 14, 1990 |
| Grant date | Feb 16, 1993 |
| Priority date | — |
| Expiry date | Aug 14, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B3/1241
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method for in vivo measurement of oxygen concentration levels in animal bodily fluids or tissues comprises administering a biocompatible fluoroescent probe sensitive to oxygen quenching and having a known unquenched fluorescence intensity to an animal body in an amount sufficient to allow the probe to accumulate in the fluid or tissue, exposing the fluid or tissue to excitation light, measuring fluorescent emission light intensity from the probe in the fluid or tissue and determining the oxygen concentration level of the fluid or tissue by comparing the known unquenched fluorescence intensity and the measured fluorescence intensity. This method preferably uses a biocompatible fluorescent probe comprising pyrenebutyric acid or its biocompatible salt form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.