Method for the preparation of optically active 3-hydroxypyrrolidine derivatives
US5187094A · kind A · utility
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8Claims
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Key dates
| Filing date | Sep 24, 1991 |
| Grant date | Feb 16, 1993 |
| Priority date | — |
| Expiry date | Sep 24, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P17/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for the preparation of optically active 3-hydroxypyrrolidine derivatives is disclosed, which comprises the steps of: hydrolyzing a mixture of (R)- and (S)-N-benzyl-3-acyloxypyrrolidine by the use of microorganisms or enzymes with stereospecific esterase activity; and separating optically active N-benzyl-3-hydroxypyrrolidine and optically active N-benzyl-3-acyloxypyrrolidine from the hydrolysate obtained in the foregoing step.
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