Topical ophthalmic suspensions

US5188826A · kind A · utility

Assignee

• Insite Vision Incorporated · US

Inventors

• Santosh K. Chandrasekaran · Moraga, US
• Margaret J. Reents · Alameda, US
• John C. Babcock · Burnaby, CA
• Lyle M. Bowman · Pleasanton, US
• Roy Duane Archibald · Angels Camp, US
• Joseph R. Robinson · Madison, US

Key dates

• Filing date: Jul 6, 1990
• Grant date: Feb 23, 1993
• Expiry date: Jul 6, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A topical, aqueous ophthalmic gel suspension for dry eye is administrable to the eye in drop form, remains as a gel in the eye for a prolonged time, and releases water and one or more ophthalmic demulcents or vasoconstrictors. It comprises water and from 0.1% to 6.5% by weight of lightly cross-linked carboxyl-containing polymer having a particle size of not more than about 50 .mu.m in equivalent spherical diameter. The suspension is at a pH of from 6.6 to 8.0, has an osmolality of from 50 to 400 mOsM, and a viscosity of from about 500 to about 4,000 centipoise (0.5 to 4 Pa.s).