Sustained release formulations
US5188836A · kind A · utility
49Cited by
3References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 27, 1990 |
| Grant date | Feb 23, 1993 |
| Priority date | — |
| Expiry date | Jul 27, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5078
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Semi-enteric controlled release formulations are comprised of a biological active agent such as an antibiotic that is blended with a water-soluble bulking agent, the mix then coated onto an inert core. The coated active core is further coated with a mixture comprised of an acrylic copolymer, bulking agent and pH dependent food acid. These different coating components possess different solubility characteristics which result in a gradual release of the active in both the stomach and small intestine that provides an increased bioavailability of the active drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.