Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
US5189164A · kind A · utility
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2References
29Claims
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Key dates
| Filing date | Feb 20, 1990 |
| Grant date | Feb 23, 1993 |
| Priority date | — |
| Expiry date | Feb 20, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for synthesizing syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof from the corresponding keto-hydroxy compounds, which process comprises: providing a reaction medium comprising sodium borohydride and an alkoxydialkylborane compound; treating the keto-hydroxy compound with said reaction medium under conditions wherein a cyclic boronate ester is formed; and cleaving the cyclic boronate ester to obtain the dihydroxy product. The product compounds, or derivatives thereof, are useful as anti-atherosclerotic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.