Process for the preparation of phenylacetic derivatives of thieno-pyridines
US5189170A · kind A · utility
4Cited by
2References
5Claims
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Key dates
| Filing date | Mar 29, 1991 |
| Grant date | Feb 23, 1993 |
| Priority date | — |
| Expiry date | Mar 29, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula: ##STR1## in which R.sub.1 and R.sub.2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: ##STR2## with CHBr.sub.3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R.sub.1 is H and R.sub.2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: ##STR3## which is useful as a medicament.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.