Ibuprofen resolution
US5189208A · kind A · utility
9Cited by
4References
9Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jul 1, 1991 |
| Grant date | Feb 23, 1993 |
| Priority date | — |
| Expiry date | Jul 1, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C51/487
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for obtaining a substantially pure enantiomer of ibuprofen is described. The process utilizes first an enantiomerically enriched mixture of ibuprofen obtained from kinetic resolution, diastereomeric crystallization or asymmetric synthesis processes. This enriched mixture is dissolved in a solvent and solid racemic ibuprofen is separated, leaving a mother liquid comprising the solvent and the enriched enantiomer substantially free of the other enantiomer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.