Triarylethylene carboxylic acids with estrogenic activity
US5189212A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 7, 1990 |
| Grant date | Feb 23, 1993 |
| Priority date | — |
| Expiry date | Sep 7, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C65/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nonsteroidal estrogenic triarylethylene carboxylic acids of the formula ##STR1## wherein R is (CH.sub.2).sub.m O or (CH.sub.2).sub.n, where m is an integer from 1 to 4 and n is an integer from 0 to 4, X is hydrogen or hydroxyl, Y is methyl, ethyl, chlorine, or bromine, and wherein the RCOOH and X moieties are either meta or para to the phenyl ethylene linkage. Examples of active compounds include 4-hydroxytamoxifen acid, 3-hydroxytamoxifen acid, 4-[1-(p-hydroxyphenyl)-2-phenyl-1-butenyl]benzoic acid and 4-[1-(p-hydroxyphenyl)-2-phenyl-1-butenyl]phenylacetic acid. Compositions containing these triarylethylene carboxylic acids can be administered to patients to alleviate medical conditions associated with a deficiency of estrogen, including osteoporosis, premenstrual syndrome, vasomotor symptoms associated with menopause, atrophic vaginitis, Kraurosis vulvae, female hypogonadism, primary ovarian failure, excessive hair growth and pr The U.S. Government has certain rights in this invention by virtue of grants from the National Institutes of Health.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.