Method for size exclusion chromatography
US5190658A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1992 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Feb 3, 2012 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/54
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
An apparatus and a method for size exclusion chromatography is provided. The apparatus is a chromatographic column adapted for use in size exclusion chromatography by having dimensions suitable for size exclusion chromatography and by having a packing material comprising generally spherical particles having wedge-shaped macropores. Preferred particles are in the shape of lamellar and/or acicular crystals extending radially outwardly from a central core region and comprise aluminum oxide, aluminum hydroxide or a mixture thereof. The method involves passing a solution of macromolecules through a column adapted for size exclusion chromatography packed with such particles. The particles effectively and efficiently separate a wide range of macromolecules in decreasing order of their molecular weight.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.