Agents for diagnosing and treating melanomas, aromatic halogenated derivatives usable as such agents and their preparation
US5190741A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Aug 6, 1991 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Aug 6, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/78
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
##STR1## The invention concerns agents for diagnosing and treating malignant melanomas, of general formula (I), in which X denotes a hydrogen or halogen atom, Y denotes a Z--CONH--, Z--O--, Z--S(O)--.sub.n1 group, n.sub.1 being equal to 0,1,2 or 3, a Z--SO.sub.2 --NH-- Z--NHCO-- group, Z being a bond, a --CH.sub.2 -- or --CH(C.sub.6 H.sub.5)-- group, n is an integer between 2 and 4, and R.sub.1 and R.sub.2 each denote a hydrogen atom, a C.sub.1 to C.sub.6 alkyl group or a C.sub.6 to C.sub.12 aryl or aralkyl group, these compounds possibly being labelled by radioisotopes chosen from .sup.123 I, .sup.123 I, .sup.123 I, .sup.75 Br, .sup.77 Br, .sup.18 F, or .sup.11 C or by stable isotopes chosen from .sup.13 C and .sup.19 F, as well as their addition salts with pharmaceutically acceptable acids. The invention also concerns the use of these compounds to manufacture an agent for diagnosing and/or treating malignant melanomas.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.