Method of administering proteins to living skin cells
US5190762A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jan 23, 1991 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Jan 23, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for administering a protein having intracellular biological activity into the interior of living skin cells, which lie below the skin's stratum corneum, is provided. The method comprises the steps of: (a) encapsulating the protein in liposomes; and (b) applying the liposomes to the outer surface of living skin so that the protein encapsulated in the liposomes traverses the skin's stratum corneum and the outer membranes of said cells and is thereby delivered by the liposomes into the interior of said cells. In certain preferred embodiments, the liposomes are pH sensitive liposomes. In other preferred embodiments, the protein is a DNA repair enzyme, such as T4 endonuclease V.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.