Process for improving the therapeutic efficacy of fat-soluble corticosteroids and composition for carrying out this process
US5190936A · kind A · utility
15Cited by
2References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1990 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Jun 13, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P29/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The process consists in dissolving a corticosteroid in the lipid phase of nonionic amphiphilic lipid vesicles consisting of one or more lipid lamellae. Composition for carrying out the above process, in which the vesicles are dispersed in an aqueous phase D, have an average diameter of between 10 and 5,000 nm and contain as corticosteroids 17- and/or 21-mono- or -diesters of hydrocortisone, cortisone, prednisone, prednisolone or 6-methylprednisolone, the corticosteroids representing 0.5 to 2.5% by weight of the total lipids of the lamellae.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.