Lactam derivatives
US5190937A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 11, 1991 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Jan 11, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D225/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel compounds of formula (I), and pharmaceutically acceptable salts thereof; their preparation; compositions containing them; and their use in the treatment of conditions in which degradation of connective tissue and other proteinaceous components of the body occurs: ##STR1## in which, R.sub.1 is --OH; alkoxy; aryloxy or aralkyloxy in each of which the aryl group is optionally substituted; --NR.sub.6 R.sub.7, where each of R.sub.6 and R.sub.7 is independently hydrogen or alkyl, or R.sub.6 and R.sub.7 together with the nitrogen atom to which they are bonded form a 5-, 6- or 7-membered ring with an optional oxygen or sulphur atom or an optionally substituted second nitrogen atom in the ring; or a group: EQU --NH--CH(R.sub.8)--C(O)--R.sub.9 where R.sub.8 is hydrogen; alkyl optionally substituted by --OH, alkoxy, --NR.sub.6 R.sub.7 as defined for R.sub.1, guanidine, --CO.sub.2 H, --CONH.sub.2, --SH, or --S--alkyl; or --CH.sub.2 --Ar where Ar is optionally substituted aryl or heteroaryl; and R.sub.9 is alkoxy; --OH; or --NR.sub.6 R.sub.7 as defined for R.sub.1 ; R.sub.2 is hydrogen; C.sub.2-8 alkanoyl; or optionally substituted aroyl; R.sub.3 is C.sub.3-6 alkyl; and R.sub.4 is --(CH.s…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.