Formulation containing S(+) enantiomer of flurbiprofen or ketoprofen and method of use for oral administration for prevention and treatment of bone loss associated with periodontal disease
US5190981A · kind A · utility
12Cited by
6References
7Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | May 28, 1991 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | May 28, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of reducing bone loss and promoting bone regrowth, once loss has occurred, particularly alveolar bone loss associated wtih periodontal disease, and a composition useful in the method. The method comprises applying to buccal membranes a therapeutically effective quantity of at least one S enantiomer, generally an S(+) enantiomer, of a nonsteroidal anti-inflammatory drug, such as S(+) flurbiprofen or S(+) ketoprofen. The composition is a formulation which is a toothpaste or which is a mouthwash.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.