Site-specific conjugation of immunoglobulins and detectable labels
US5191066A · kind A · utility
23Cited by
6References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 7, 1990 |
| Grant date | Mar 2, 1993 |
| Priority date | — |
| Expiry date | Dec 7, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/1077
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A process for producing a derivatized immunoglobulin and conjugates prepared therewith are provided. The derivatized immunoglobulin is produced by introducing sulfhydryl groups in the Fc region of an immunoglobulin wherein the Fab portion of the immunoglobulin is not altered. The derivatized immunoglobulin is used to prepare conjugates with various detectable moieties wherein a controlled distance exists between the Fc region of the immunoglobulin and the detectable moiety. The conjugates are particularly useful for performing immunoassays, and exhibit improved longevity, specificity and sensitivity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.