Method of amphiphatic drug loading in liposomes by pH gradient
US5192549A · kind A · utility
263Cited by
4References
2Claims
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Key dates
| Filing date | Sep 27, 1989 |
| Grant date | Mar 9, 1993 |
| Priority date | — |
| Expiry date | Sep 27, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2984
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An improved simple, efficient, safe, economical, and fast transmembrane loading procedure for efficient active loading of weak amphiphatic drugs into liposomes using the transmenbrane gradient. The resulting liposomes loaded with the amphiphatic drug are stable and safe. A storageable form of loadable liposomes has extended period of stability. The reversed procedure is applicable for sustained release of liposome encapsulated drugs from ammonium liposomes.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.