Sustained and controlled release of water insoluble polypeptides
US5192741A · kind A · utility
141Cited by
4References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 20, 1988 |
| Grant date | Mar 9, 1993 |
| Priority date | — |
| Expiry date | Sep 20, 2008 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/09
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.