Derivatives of 2-aminoalkyl-5-arylalkyl-1,3-dioxanes, their preparation and their therapeutic application
US5192797A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 14, 1991 |
| Grant date | Mar 9, 1993 |
| Priority date | — |
| Expiry date | Jun 14, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/26
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound which is a 2-aminoalkyl-5-arylalkyl-1,3-dioxane of general formula (I) ##STR1## in which m represents 0 or 1; PA1 n represents 1, 2, 3 or 4; PA1 R.sub.1 represents hydrogen or methyl; PA1 R.sub.2 represents hydrogen, methyl or an alkanoyl group of the general formula COR' in which R' represents a hydrogen atom or a linear or branched C.sub.1 -C.sub.4 -alkyl group, or an alkoxycarbonyl group of the general formula COOR" in which R" represents a linear or branched C.sub.1 -C.sub.4 -alkyl group; and Ar represents either a phenyl group optionally carrying one or two substituents selected from halogen, C.sub.1 -C.sub.4 alkyl, methoxy and trifluoromethyl, or a naphthalen-1-yl or naphthalen-2-yl group optionally carrying a substituent selected from halogen, methyl, methoxy and cyclopropylmethoxy groups, PA1 in the form of a cis- or trans-stereoisomer, and in the form of a free base or an acid addition salt thereof and its therapeutic use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.