Amphotericin B/cholesterol sulfate composition and method
US5194266A · kind A · utility
102Cited by
1References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 1991 |
| Grant date | Mar 16, 1993 |
| Priority date | — |
| Expiry date | Dec 19, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 2:1. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 50-250 nm. The composition has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.