Malaria-specific DNA sequences, expression products thereof, and the use thereof

US5194587A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Bernhard Knapp · Marburg, DE
• Erika Hundt · Marburg, DE
• Burkhard Enders · Marburg, DE
• Hans Kupper · Marburg, DE

Key dates

• Filing date: Jun 27, 1991
• Grant date: Mar 16, 1993
• Expiry date: Jun 27, 2011

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/82
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to malaria-specific DNA sequences, to the expression products thereof, and to the use thereof. A combination of three of the expression proteins whose DNA sequences were isolated by screening a lambda gt11 gene bank with a monospecific antiserum against the protective 41kD antigen bend from P. falciparum protects Aotus monkeys completely from a P. falciparum infection in model experiments.