Aminoalcohol intermediates for peptide derivatives

US5194588A · kind A · utility

Assignee

• ICI Americas, Inc. · US

Inventors

• Philip D. Edwards · Claymont, US
• John A. Schwartz, Jr. · Spartanburg, US
• Mark M. Stein · Wilmington, US
• Diane A. Trainor · Glen Mills, US
• Richard A. Wildonger · Elmwood, US

Key dates

• Filing date: Mar 9, 1990
• Grant date: Mar 16, 1993
• Expiry date: Mar 9, 2010

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.