Ethylene-substituted phenylalkylethylene-diamine-platinum (II or IV) derivatives and phenylalkylethylenediamines

US5194644A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Henri Brunner · Lappersdorf, DE
• Peter Hankofer · Cologne, DE
• Friedrich Maiterth · Hagelstadt, DE
• Jurgen Engel · Alzenau, DE
• Wolfgang Schumacher · Langen, DE
• Peter Hilgard · Frankfurt, DE
• Rainer Voegeli · Bielefeld, DE

Key dates

• Filing date: Apr 10, 1991
• Grant date: Mar 16, 1993
• Expiry date: Apr 10, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/28
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antitumor acting platinum(II or IV) complexes of the general formula ##STR1## where B represents a phenyl-C.sub.1 -C.sub.4 -alkyl radical which is optionally substituted in the phenyl nucleus by the radical R.sub.1 and R.sub.1 is hydrogen, halogen, trihalogen methyl, C.sub.1 -C.sub.6 -alkyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy or C.sub.2 -C.sub.6 -alkanoyloxy or where B together with the structural part H.sub.2 N--CR.sub.2 <forms a tetrahydroisoquinoline radical, if B contains benzyl and R.sub.2 hydrogen and the benzyl radical in the 2-position contains the CH.sub.2 -radical or where B together with the structural part --CR.sub.2 < represents a tetrahydronaphthyl radical in which one CH.sub.2 group is optionally replaced by oxygen, or where B together with the structural part --CR.sub.2 < represents a decahydronaphthyl radical or an indanyl radical; R.sub.2 represents hydrogen, C.sub.1 -C.sub.6 -alkyl, phenyl or phenyl-C.sub.1 -C.sub.4 -alkyl, it also being possible for the phenyl ring of this group R.sub.2 to be substituted by hydroxy, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.6 -alkanoyloxy or halogen; the radicals R.sub.3 and R.sub.4 are the same or differe…