Process for the preparation of .beta.-ketocarboxylic acid esters
US5194671A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Mar 11, 1992 |
| Grant date | Mar 16, 1993 |
| Priority date | — |
| Expiry date | Mar 11, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/343
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to a process for the preparation of .beta.-ketocarboxylic acid esters of the general formula ##STR1## in which R.sup.1 is an alkyl radical having 1 to 4 C atoms, R.sup.2 is an alkyl radical or alkenyl radical having 2 to 15 C atoms or a phenyl radical and R.sup.3 is hydrogen or an alkyl or alkenyl radical having 1 to 6 C atoms, characterized in that acetocarboxylic acid esters of the general formula ##STR2## in which R.sup.1 and R.sup.3 are as defined, are reacted with calcium hydroxide or calcium oxide in the presence of an organic solvent and in the absence of water, the calcium chelate complexes formed are acylated with carboxylic acid chloride and the products are then cleaved with aqueous ammonium salt solution to form the .beta.-ketocarboxylic acid esters of formula (I). The .beta.-ketocarboxylic acid esters readily accessible by the process according to the invention can be used as important intermediates in the synthesis of pharmaceutically active ingredients or plant protection agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.