Gallium compounds
US5196412A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Mar 6, 1991 |
| Grant date | Mar 23, 1993 |
| Priority date | — |
| Expiry date | Mar 6, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D211/94
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to compounds of gallium (III) which can be given orally to achieve high serum levels of gallium (III) for the treatment of hypercalcemia of malignancy and related disorders of bone metabolism. Complexes of gallium (III) of the formula (I) ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.8 n-alkyl and R.sub.2 is H or C.sub.1 -C.sub.2 alkyl, or R.sub.1 and R.sub.2 together form tetra- or penta-methylene and wherein said complex is useful in increasing calcium content of bone tissue and decreasing bone resorption, are used in an amount sufficient to cause an increase in calcium content of said bone and to cause decreased bone resorption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.