Diaryl-substituted heterocyclic compounds, their preparation and drugs and cosmetics obtained therefrom

US5196532A · kind A · utility

Assignee

• BASF SE

Inventors

• Hans-Heiner Wuest · Dossenheim, DE
• Bernd Janssen · Ludwigshafen, DE
• William V. Murray · Montgomery, US
• Michael P. Wachter · Bloomsbury, US
• Stanley C. Bell · Narberth, US

Key dates

• Filing date: Jun 18, 1991
• Grant date: Mar 23, 1993
• Expiry date: Jun 18, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/24
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## where R.sup.1 and R.sup.2 are each hydrogen or methyl, A is an ethylene or methylene radical which is unsubstituted or substituted by methyl, hydroxyl or oxo, PA0 L is a saturated or unsaturated five-membered or six-membered heterocyclic structure which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.6 -alkyl, or C.sub.1 -C.sub.4 -alkanoyl and has from 1 to 3 heteroatoms from the group consisting of N, O and S, the second and third heteroatoms being a nitrogen atom, PA0 R.sup.3 is hydrogen, a hydroxy or C.sub.1 -C.sub.6 -alkoxy group, PA0 R.sup.4 is hydrogen, C.sub.1 -C.sub.4 -alkyl, halogen or methoxy, PA0 R.sup.5 is hydrogen or methoxy or tert-butyl, PA0 R.sup.6 is hydrogen methyl, nitrile or a C.sub.2 -C.sub.10 -ketal group or the radical --CHR.sup.7 OR.sup.8 --CHR.sup.7 --NR.sup.9 R.sup.10, --COR.sup.11, --SR.sup.12, ##STR2## in which R.sup.7 is hydrogen or C.sub.1 -C.sub.4 -alkyl, PA0 R.sup.8 is hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.20 -alkanoyl or is benzoyl which is unsubstituted or substituted by methoxy, nitro, methyl or chlorine, PA0 R.sup.9 and R.sup.10 are each hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub…