2-Fluoro-1-methylpyridinium salt activated diols and polyols as cross-linkers
US5196536A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 16, 1992 |
| Grant date | Mar 23, 1993 |
| Priority date | — |
| Expiry date | Apr 16, 2012 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54353
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A novel class of cross-linking agent, which comprises a monomeric organic compound having at least two hydroxyl groups each bonded to a different carbon atom, wherein said hydroxyl groups are activated by reaction with 2-fluoro-1-methylpyridinium toluene-4-sulfonate (FMP). Suitable monomeric organic compounds include diols and polyols. Such cross-linking agents may be conveniently prepared by reaction of the monomeric organic compound with FMP in a suitable solvent, followed by recovery of the resultant reaction products, e.g., via precipitation and filtration. The novel cross-linking agents have a wide variety of uses, including the interconnection of subunits of multimeric enzymes and the covalent immobilization of organic ligands to suitable carriers or supports.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.