Physiologically active substance TAN-931, its derivatives, their production and use
US5196564A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 27, 1991 |
| Grant date | Mar 23, 1993 |
| Priority date | — |
| Expiry date | Feb 27, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D313/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel compound of the formula (I): ##STR1## wherein R.sub.1 is esterified carboxyl; R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl; A is formyl, hydroxyiminomethyl or carboxyl; and X is hydrogen or halogen, or a salt thereof, which is useful as an aromatase inhibitor or an intermediate of its production. Processes for producing the compound of the formula (I) and an aromatase inhibitor containing as an active component the compound of the formula (I) wherein A is formyl and X is hydrogen or, a salt thereof as well as Penicillium funiculosum capable for producing the compound (I) wherein R.sub.1 is carboxyl, R.sub.2, R.sub.3 and R.sub.4 are hydrogen and X is formyl are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.