Compounds useful in enzymatic resolution systems and their preparation
US5196568A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 7, 1988 |
| Grant date | Mar 23, 1993 |
| Priority date | — |
| Expiry date | Apr 7, 2008 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/00177
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to novel compositions of matter which are esters with enhanced water solubility, for use in aqueous enzymatic resolution reactions of racemic mixtures of these esters for producing the separate chiral isomers of the racemic mixture. The invention also relates to novel methods for preparing these esters. The importance of the production of the separate chiral isomers of the racemic mixtures resides in the isolation of the isomers which frequently have different biological activities. Of particular significance regarding the water soluble esters of this invention is that they are derivatized with groups which enhance their aqueous solubility and their reactivity with enzymatic resolving methods which are mediated in an aqueous environment. In addition, the importance of these compounds resides in their being useful in novel methods for facilitating the enzymatic resolution reactions of racemic mixtures of esters, which are derivatized with groups which enhance the esters' aqueous solubility, in 1) a homogeneous aqueous reaction system where an extractive phase is not present, 2) a multiphase dispersion extractive reaction where an extractive phase is present, a…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.