Leukotriene-B.sub.4 derivatives, process for their production and their use as pharmaceutical agents

US5196570A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Bernd Buchmann · Hohen Neuendorf, DE
• Werner Skuballa · Berlin, DE
• Joseph Heindl · Berlin, DE
• Wolfgang Frohlich · Berlin, DE
• Roland Ekerdt · Berlin, DE

Key dates

• Filing date: Nov 16, 1990
• Grant date: Mar 23, 1993
• Expiry date: Nov 16, 2010

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C69/732
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new leukotriene-B.sub.4 analogs of formula I, ##STR1## in which R.sub.1 means radicals CH.sub.2 OH, CH.sub.3, CF.sub.3, COOR.sub.4, or radical CONHR.sub.5, PA0 A means a trans, trans--CH.dbd.CH--CH.dbd.CH-- group, trans--CH.sub.2 --CH.sub.2 --CH.dbd.CH-- group or tetramethylene group, PA0 B means a straight-chain or branched-chain, saturated or unsaturated alkylene group with up to 10 C atoms, PA0 D means a direct compound, oxygen, sulfur, a --C.tbd.C--group or a --CH.dbd.CR.sub.6 --group, PA0 B and D together mean a direct bond, PA0 R.sub.2 means a hydrogen atom or an acid radical of an organic acid with 1-15 C atoms and PA0 R.sub.3 means a hydrogen atom, an optionally substituted alkyl radical with 1-10 C atoms, a cycloalkyl radical with 3-10 C atoms, an optionally substituted aryl radical with 6-10 C atoms or a 5-6-member heterocyclic radical and, if R.sub.4 means a hydrogen atom, their salts with physiologically compatible bases and their cyclodextrin clathrates, process for their production and their pharmaceutical use.