Molecular probing for human T-cell leukemia and lymphoma
US5198338A · kind A · utility
43Cited by
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16Claims
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Key dates
| Filing date | May 31, 1989 |
| Grant date | Mar 30, 1993 |
| Priority date | — |
| Expiry date | May 31, 2009 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/255
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A very specific area of chromosome 10, band q11 is taught to be the site of chromosome breakpoints which occur in the course of translocations. The translocation brings sequences of the T-cell antigen receptor delta locus into adjacency with the specific area on chromosome 10. The area of chromosome 10 is presumed to carry an oncogene which is activated by the proximity to the delta locus. Methods and molecular probes and primers are taught for determining the presence of this particular translocation.
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