(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5198442A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 12, 1992 |
| Grant date | Mar 30, 1993 |
| Priority date | — |
| Expiry date | Feb 12, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound selected from the group consisting of those having the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.4 are independently selected from the group consisting of H and alkyl radicals having 1 to 4 carbon atoms; the R.sub.2 s are each of H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the R.sub.3 s are each H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo, provided that the R.sub.2 s or the R.sub.3 s are alkyl radicals; the 2-imidazolin-2-ylamino group may be in any of the 5-, 6, 7- or 8-positions of the quinoxaline nucleus; and R.sub.5, R.sub.6 and R.sub.7 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals having 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired thereapeutic effects, such as alternation in the rate of fluid transport in the gastrointestianl tract, reduction in intraocular pressure, and increase in renal fluid flow.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.