Process for the preparation of phenylethanolaminotetralins
US5198586A · kind A · utility
1Cited by
9References
9Claims
0Family size
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Key dates
| Filing date | Oct 25, 1990 |
| Grant date | Mar 30, 1993 |
| Priority date | — |
| Expiry date | Oct 25, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C233/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of phenylethanolaminotetralins of formula ##STR1## wherein X is hydrogen, a halogen, a trifluoromethyl or a lower alkyl group and R.degree. is hydrogen or a methyl group substituted by a carboxy or a lower carbalkoxy group, which comprises treating a mandelic acid with a 2-amino-7-hydroxytetralin, optionally alkylating with a lower alkyl haloacetate and reducing the amido group of the mandelamide into a methyleneamino group. The mandelamides intermediates are novel.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.