Pharmaceutical sustained release matrix and process
US5200193A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 22, 1990 |
| Grant date | Apr 6, 1993 |
| Priority date | — |
| Expiry date | Oct 22, 2010 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A pharmaceutical sustained release homogeneous tablet or homogeneous tablet layer is formed by making a wet granulation using povidone (PVP) in alcohol as the granulating fluid which is mixed with a pharmaceutical active, ethylcellulose, a wicking agent, e.g. microcrystalline cellulose, an erosion promoter, e.g. pregelatinized starch, then drying and milling the granulation and blending with a dry powdered erosion promotor, wicking agent, lubricant, e.g. magnesium stearate and glidant, e.g. silicon dioxide, and compressing the resultant granulation, which upon administration results in a long-lasting slow and relatively regular incremental release of the pharmaceutical active, and multi-layered pharmaceutical active tablets comprising immediate release and/or sustained release layers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.