Method for identifying useful polypeptide vaccines
US5200320A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 7, 1987 |
| Grant date | Apr 6, 1993 |
| Priority date | — |
| Expiry date | Dec 7, 2007 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of identifying potential polypeptide vaccines to an agent, such as viruses, bacteria, and parasites. A critical binding segment of a first polypeptide known to bind to a first MHC type, is ascertained. The effect of replacing each of the amino acids in the critical segment, upon binding of that segment to the first MHC type, is evaluated. Following this, a protein produced by the agent is scanned for at least one trial amino acid sequence which the foregoing evaluation indicates will be a good binder to the first MHC type. When a potentially good binding sequence is found, a polypeptide containing such sequence can be evaluated as a synthetic vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.