Lipid excipient for nasal delivery and topical application
US5200393A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Aug 27, 1991 |
| Grant date | Apr 6, 1993 |
| Priority date | — |
| Expiry date | Aug 27, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are described for liquid or gel forms of a lipid excipient to be used in pharmaceutical or cosmetic preparations. The lipid excipient comprises a phospholipid such as a lysophospholipid, for example, mono-oleoyl-phosphatidylethanolamine ("MOPE"). Relatively low concentrations of the lipid can be employed in forming the gel, e.g., about 1-2%. The invention discloses the use of a lipid delivery system at a relatively low lipid concentration as a non-toxic, non-irritating carrier or excipient alone or in combination with other agents, for both drugs and cosmetics. For example, the lipid excipient in sprayable or droppable form has special utility in the non-irritating delivery of peptides (e.g., calcitonin and insulin) to the nasal mucosa, due to the ability of the excipient to enhance absorption across nasal membranes. As a cosmetic, it can be used alone or in combination with biologically active agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.