Method for inhibiting allograft rejection using photoactivatable nucleotides or nucleosides
US5200400A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 12, 1991 |
| Grant date | Apr 6, 1993 |
| Priority date | — |
| Expiry date | Jul 12, 2011 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/70
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method for inhibiting acute rejection of a transplanted organ or tissue by a recipient mammal that includes the steps of administering to the mammal a compound which causes selective sensitization of the alloreactive lymphocytes of the transplant recipient that are involved in the rejection process to a toxin; and exposing the mammal to the toxin to selectively destroy the sensitized alloreactive lymphocytes to a greater extent than non-sensitized cells of the mammal. This method induces donor specific tolerance in the transplant recipient, i.e., acceptance of the new organ or tissue without suppression of the rest of the recipient's normal immune system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.